0.1%他克莫司软膏联合积雪苷霜软膏治疗面部糖皮质激素依赖性皮炎.docVIP

0.1%他克莫司软膏联合积雪苷霜软膏治疗面部糖皮质激素依赖性皮炎 　　[摘要]目的：探讨0.1%他克莫司联合积雪苷霜软膏对面部糖皮质激素依赖性皮炎的治疗效果和安全性。方法：选择我院2010年3月～2013年5月皮肤门诊收治的60例面部糖皮质激素依赖性皮炎患者作为研究对象，按照随机数字表分为观察组和对照组。观察组30例，采用外用0.1%他克莫司软膏治疗4周，停药后再使用积雪苷霜软膏继续护肤20周；对照组30例，仅外用0.1%他克莫司软膏治疗4周。共观察24周，对比两组疗效。结果：治疗后，观察组患者的面部红斑、脱屑、丘疹、脓疱、色素沉着等症状积分均较对照组出现了明显改善，组间差异具有统计学意义（P0.05），观察组总有效率为86.7%，明显高于对照组，组间差异具有统计学意义（P0.05），两组患者的不良反应基本相当。结论：0.1%他克莫司软膏联合积雪苷霜软膏治疗面部糖皮质激素依赖性皮炎具有十分显著的疗效，可明显改善患者的临床症状，提高疗效，安全可靠，值得临床应用。 　　[关键词]0.1%他克莫司；积雪苷霜软膏；面部糖皮质激素依赖性皮炎；安全性 　　[中图分类号]R758.22 [文献标识码]A [文章编号]1008-6455（2014）17-1458-03 　　Efficacy of 0.1% tacrolimus ointment combined with asiaticoside cream ointment for treatment of facial corticosteroid dependent dermatitis 　　XU Jing 　　（Department of Dermatology，Suzhou Municipal Hospital North District，Suzhou 215000，Jiangsu，China） 　　Abstract：Objective To investigate the efficacy of 0.1% tacrolimus ointment combined with asiaticoside cream ointment for treatment of facial corticosteroid dependent dermatitis. Methods 60 cases with facial corticosteroid dependent dermatitis were included in the study， of which the observation group of 30 patients was treated with 0.1% tacrolimus ointment cream for 4 weeks， then treated with asiaticoside for 20 weeks， while the control group of 30 patients was treated with 0.1% tacrolimus monotherapy for 4 weeks.The clinical efficacy and safety for two groups were compared. Results Scaling，papules，pustules， pigmentation and other symptom scores in the observation group had significantly improved （P0.05） than the control group. The total effective rate of the observation group was 86.7%， significantly higher than the control group （P0.05）. Side effects for two groups were comparable. Conclusion 0.1% tacrolimus ointment combined asiaticoside in treatment of facial cream ointment corticosteroid dependent dermatitis has a very significant effect，which can significantly improve the clinical symptoms， improve patient outcomes and it is worthy of clinical application. 　　Key words：0.1% tac