中药温胆汤改善失眠后焦虑.docVIP

中药温胆汤改善失眠后焦虑 既往研究显示中药温胆汤对失眠引起的诸多症状均有治疗改善作用，该作用是否与“脑肠轴的失衡”有关呢？中国北京中医药大学王丽晔Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin”的研究，发现睡眠剥夺大鼠会出现焦虑，给予温胆汤干预可有效减少焦虑的发生，且与脑肠肽有关，这一结论再次验证脑肠肽中枢及胃肠道的双重功能。王丽晔及其同事选择内源性脑肠肽及内源性脑肠肽受体进行研究，他们发现睡眠剥夺可使内源性脑肠肽表达减少，内源性脑肠肽受体mRNA增多，而温胆汤降低大鼠下丘脑中内源性脑肠肽Article: Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin, by Liye Wang, Yuehan Song, Feng Li, Yan Liu, Jie Ma, Meng Mao, Fengzhi Wu, Ying Wu, Sinai Li, Binghe Guan, Xiaolan Liu Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing 100029, China Wang LY, Song YH, Li F, Liu Y, Ma J, Mao M, Wu FZ, Wu Y, Li SN, Guan BH, Liu XL. Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin. Neural Regen Res. 2014;9 2 :205-212. 欲获更多资讯：Neural Regen ResWen Dan Tang improves insomnia-related anxiety Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang’s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a research team from Beijing University of Chinese Medicine in China generated a sleep deprivation rat model, and orally administered Wen Dan Tang. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang’s regulation of Ghrelin-Ghrelin receptors. The relevant paper has been published in the Neural Regeneration Research Vol. 9, No. 2, 2014 . After 14 days of Wen Dan Tang