Lecture5TCell-MediatedImmunity-Universityof.pptVIP

Lecture 5Effector Mechanisms Host Defense Effector Mechanisms Antibody-mediated Neutralizing Opsonization Complement activation Receptor-mediated Antibody-dependent cellular cytotoxicity Cell-mediated Direct cytotoxicity (induction of apoptosis) Cytokines Regulatory T-cell Mediated Cytotoxicity Necrosis Programmed cell death or apoptosis Cytokines Polypeptides produced by a variety of cell types including T lymphocytes used for communications between cells. Cytokine production is triggered by specific receptor binding and subsequent signal transduction pathways Cytokine repertoire is depend