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Paul Thomas Francis 教授 Paul Thomas Francis, 博士/教授 （英国） 伦敦大学 - 国王学院- Wolfson 老年相关疾病中心 研究方向： 神经、精神药理、病理及相关机制 主要职务： 英国药理学会委员、神经科协会委员、实验神经学编委会委员 国际老年精神药理学学院 主要创始人 痴呆研究项目 （AD研究协会）负责人 Paul教授从事神经精神科研工作数十年，80年代开始神经科学研究，随 后着重在多种神经递质、认知障碍机理等方面探索。Francise教授是很 多国际多中心研究的牵头人或与他人合作进行多项大型基础研究。在 国际主要期刊（. Neurosci Lett, . Psychopharmacology. J Alzheimers Dis, ets）上发表上百篇学术论文。 痴呆的谷氨酸能机制: 美金刚, 对症治疗还是保护性治疗? Paul Francis Wolfson Centre for Age-Related Disease, GKT School of Biomedical Science King’s College London London UK AD的谷氨酸 探讨美金刚对行为症状（如激越/攻击行为）的作用机制 美金刚保护效应的证据 4x3 .PFIZER.ARICEPT.Sample * * * The levels of APP, the precursor molecule of Aβ peptides, were not significantly altered after memantine treatment, nor were the levels of fragments C99 and C38, which are by-products of APP processing by the Aβ-generating enzymes ADAM10 and BACE A and B . The levels of APP/amyloid-processing molecules ADAM10, BACE, IDE, and TTR were also unaffected by memantine treatment data not shown . However, the levels of Aβ*56, the 12-mer amyloid-β aggregate, were significantly lower in memantine-treated 3xTg-AD mice A and B as were the levels of prefibrillar Aβ oligomers in both male and female mice and fibrillar Aβ oligomers in females only; C and D . Densitometric analyses of Western and dot blots indicate that memantine treatment of 3xTg-AD mice significantly reduces the levels of the dodecamer Aβ*56 A, B and total prefibrillar oligomers A11 in both males and females C, D , but total fibrillar oligomers OC in female mice only C, D . *p 0.05 Mice were anaesthetised and sacrificed in CO2 chambers. The brains were excised, and one half was fixed in 4% paraformaldehyde for immunohistochemical analyses; the other half was frozen on dry ice and used for protein extraction, Western blot, and ELISA. Immunohistochemical sections were visualised using diaminobenzedine. Antibody D32 is specific for Aβ residues 35–42. * * * Procter AW, Francis PT, Holmes C, Webster M-T, Qume M, Stratma