18f-fdgpetctforthediagnosisoftumorthrombosis.pptVIP

18F- FDG PET/CT in the Diagnosis of Tumor Thrombosis T Davidson1, E Konen2 , O Goitein2, A Avigdor3, S T Zwas1 , E Goshen1 Departments of Nuclear Medicine1, Radiology2 and Hemato-Oncology3 Sheba Medical Center, Tel Aviv University, Israel Background Venous Thrombo-Embolism (VTE): well-recognized relatively frequent complication of malignancy Tumor Thrombosis: a rare complication in this condition Largest series described six cases of Tumor Thrombosis diagnosed by PET with simultaneous CT Lai P, et al. Detection of tumour thrombus by 18F-FDG-PET/CT imaging. Eur J Cancer Prev. 2007 Feb;16(1):90-4. Background The role of PET/CT in the diagnosis of Tumor Thrombosis The Differential diagnosis of Tumor Thrombosis from Venous Thrombo-Embolism Aims Materials and Methods Retrospective study of PET/CT scans 10 patients with suspected intravascular thrombosis on either PET/CT or contrast enhanced CT scans 6 M, 4 F; Age 31-76 (mean 53.5 y) Materials and Methods In 8/10 pts the intravascular lesion was an incidental finding on PET-CT scan during investigation of patients with known malignancy 2/10 pts were referred to PET-CT for further evaluation of a known intravascular lesion diagnosed on CT /MRI Materials and Methods Criteria for a positive PET : Increased focal or linear uptake of 18F-FDG in the involved vessel Standard uptake value (SUV) above 2.5 Materials and Methods Findings were categorized: PET positive (+) or PET negative (-) Compared to contrast enhanced CT ultrasound doppler, pathology when available, clinical follow-up 7/10 patients showed PET(+) with Tumor Thrombosis The other 3