veryhighresolutionsmallanimalpet-physics.pptVIP

Very High Resolution Small Animal PET Don J. Burdette Department of Physics What is PET? Answer: Cancerous cells have a higher metabolism than normal cells, thus PET scans detect cancer. Other Uses for PET include detection of Cardiovascular Disease, Alzheimer’s disease, Parkinson’s disease, epilepsy, and other neurological disorders. How does PET work? How does PET work? Small Animal PET Systems biomedical, pharmaceutical, and genetic manipulation research Mice are used as human disease models A single mouse can be used to tract disease development and treatment Important for genetically altered specimens MicroPET R4 from University of Michigan’s PET center Silicon Detectors Characteristics of ideal Silicon detector for use in PET: Thick detector to increase efficiency 1mm compared to typical 0.3mm thickness Small detection pads for excellent spatial resolution Custom made readout chips including an amplifier, and sample-hold switch Chips have trigger logic to allow independent silicon operation Experimental Set-up Reconstructing the Data for a Simulated Disk Source Reconstructing the Data for a Simulated Disk Source Reconstructing the Data for a Simulated Point Source Reconstructing the Data for a Simulated Disk Source Experimental Results Our small animal PET set-up Resolution of 0.7mm From microPET R4 set-up Resolution of 1.8mm Conclusion and Future Work Our prototype Small Animal PET achieves a system resolution below the 1mm goal demonstrating the usefulness of silicon in Small Animal PET applications. Future Work includes: Add a stack of silicon detectors to increase efficiency Improve rate capabilities by decreasing coincidence window This can be accomplished by taking advantage of the Compton scattered photon and using a secondary detector with faster coincidence timing Silicon timing 200ns coincidence window, timing from some scintillation crystals approach 60ns References Miles N. Wernick and John N. Aarsvold, editors. Emission Tomography: The