夹尾体感刺激抑制大鼠海马CA1区锥体神经元的兴奋性.docVIP

夹尾体感刺激抑制大鼠海马CA1区锥体神经元的兴奋性 大脑海马区负责实现学习和记忆，但是它对于外界感觉输入信息的处理机制尚不清楚。中国浙江大学封洲燕博士所在团队利用微电极阵列在大鼠海马区监测神经元的活动，发现夹尾的感觉刺激会诱发不同种类神经元产生不同的响应。其中，锥体神经元放电减少，而抑制性中间神经元放电却会增加。而且，在锥体神经元输入通道上直接施加电刺激的测试结果也表明，在夹尾体感刺激期间锥体神经元的兴奋性有所下降。这些研究结果为揭示海马区的信息处理机制提供了新线索。此外，由于海马区是癫痫等大脑疾患的易发区域，体感刺激的这种抑制性作用还可以为治疗神经组织过度兴奋状态相关疾病提供新思路。相关文献发表于《中国神经再生研究（英文版）》杂志2014年6月第11期。 Article: Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region in rats, by Yang Wang, Zhouyan Feng, Jing Wang, Xiaojing Zheng Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrumentation Science, Zhejiang University, Hangzhou, Zhejiang Province, China Wang Y, Feng ZY, Wang J, Zheng XJ. Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region in rats. Neural Regen Res. 2014;9 11 :1138-1144. 欲获更多资讯： Neural Regen Res Somatosensory stimulation inhibits excitability of pyramidal cells in rat hippocampal CA1 The hippocampal region of the brain is important for encoding environment inputs and memory formation. However, the underlying mechanisms are unclear. Dr. Zhouyan Feng and co-workers from Zhejiang University, China monitored the activity of hippocampal neurons in rats using microelectrode arrays, and explored the mechanisms underlying the neuronal responses. Somatosensory stimulation, in the form of tail clamping, changed local field potentials into theta rhythm-dominated waveforms, decreased the spike firing of pyramidal cells, and increased interneuron firing. In addition, somatosensory stimulation attenuated orthodromic-evoked population spikes. These results suggest that somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region. Increased inhibition by local interneurons might underlie this effect. These findings, published in the Neural Regeneration Research Vol. 9, No. 11, 2014 , provide insight into the mechanisms of signal processing