Chapter7-3脂的代谢解答.ppt

化学反应式 烯脂酰辅酶A转变为羟脂酰辅酶A 硫酯解酶的作用机理 不饱和和脂肪酸的β-氧化 多双键脂肪酸的氧化 奇数碳脂肪酸的β-氧化 甲基丙二酰辅酶A异构机理 β-氧化是四步反应的循环 Sources of NADPH for Fatty Acid Synthesis Oxaloacetate formed in the transfer of acetyl groups to the cytosol must now be returned to the mitochondria. The inner mitochondrial membrane is impermeable to oxaloacetate. Hence, a series of bypass reactions are needed. Most important, these reactions generate much of the NADPH needed for fatty acid synthesis. First, oxaloacetate is reduced to malate by NADH. This reaction is catalyzed by a malate dehydrogenase in the cytosol. Second, malate is oxidatively