40糖尿病药物治疗1123课件.pptVIP

糖 尿 病 药 物 治 疗 张 国 超 中山大学附属第三医院内分泌科 Biguanides 1957 Sulphonylureas 1957 Prandial glucose regulators Metiglinide (1997), Nateglinide (2000) α- Glucosidase inhibitors 1990 Thiazolidinediones 1997 Sulfonylureas (SUs) Mechanism of action: Increased insulin secretion Advantages: Well established, decreases microvascular risk, convenient daily dosing, monotherapy and combination. Disadvantages: Hypoglycemia, weight gain, hyperinsulinemia (role uncertain). Biguanides (Metformin) Mechanism of action: Decreased hepatic glucose production, increased insulin sensitivity in