生物活性论文：类噻唑类衍生物的合成研究.docVIP

生物活性论文：几类噻唑类衍生物的合成研究 【中文摘要】本论文包括四部分内容,主要工作是关于噻唑类化合物、噻唑席夫碱、及其它衍生的合成的研究：1.综述了噻唑类杂环化合物近年来的应用价值及合成方法的研究,噻唑类衍生物以其独特的结构特点而具有良好的药理活性和生物活性,如杀菌、抗肿瘤、抗病毒和除草等生物活性,在医药、农药、香料等领域均有相当重要的应用研究价值,越来越多的科学工作者开始对这类化合物进行研究；噻唑类杂环化合物的合成方法有很多,本论文对它的一些合成方法进行了详尽的阐述,并且提出了本课题的选择依据及意义。2.采用新型的合成方法合成了6种2-氨基噻唑类化合物,并对它的合成条件进行了探讨研究,同时提出了此反应可能的反应机理；在此基础上,本论文合成了20种噻唑类席夫碱,并对这类席夫碱的合成条件进行了探讨；通过IR,1HNMR,13C NMR表征确定了2-氨基噻唑类化合物及其席夫碱的结构。3.4-甲基-5-(2-羟乙基)噻唑(MHT)作为一种重要的合成中间体,在医药行业有一定的需求,同时它也在一些有机化学反应中作为一种卡宾催化剂,其中还有一重要的用途是作为食品添加剂；本论文采用了一种新型的合成方法制取了4-甲基-5-(2-羟乙基)噻唑,以便宜易得的5-羟基-2-戊酮原料,SO2Cl2代替Cl2进行了氯代反应,本实验成本低,毒性小,目标分子及中间体通过了IR,1H NMR确认了其结构。4. Alibendol是一种优良的新型抗痉挛利胆药物,其化学名称为2-羟基-N-(2-羟乙基)-3-甲氧基-5-(2-丙烯基)苯甲酰胺,药理研究证明其毒性低,利胆作用明显,可用于荨麻疹、胃病、搔痒等疾病；本论文合成了5种未见文献报道的Alibendol的衍生物,通过IR,1H NMR表征确定了这5类化合物的的化学结构。 【英文摘要】The thesis includes four chapters, and its’ prime task involves the thiazole derivatives, thiazole species Schiff base and other derivatives synthesis research:1. The chapter is a brief review for the research about application values and synthesis methods of thiazole derivatives in recent years. Because of their special configuration, thiazole heterocyclic derivatives have wide-ranging pharmacological and biological activities, such as antifungal, anticancer, antiviral, herbicidal; and they also have a value of applications and researchs in the areas of medicinal chemistry, pesticide, perfume and other fields, more and more scientists have a great interesting on researching them. There are many synthesis methods for thiazole heterocyclic derivatives, some synthesis of them are described comprehensively in this paper; then we put forward background and significance of the research.2. We obtain six compounds of 2-aminothiazoles by using a novel synthesis methods, and the effects of reaction condition on them were studied, and the same time, the reasonable reaction mechanism is deduced; we get 20 thiazole species Schiff base on that basis, also the synthetic conditions of them were studied. All the products and the