工业化生物发酵术——清华大学国际技术转移中心.doc

Biotechnology Catalogue Version 201306 Note: Most of the following technologies are for A.P.I.s, and they have been successfully commercialized in the market. 工业化生物发酵技术（原料药） Product名称 Guaranteed Values指标 ACARBOSE阿卡波糖Final titre: 8-9g/lt Fermentation time: 120-144hrs Recovery yield: 55% ACLARUBICIN 阿柔比星 Two step fermentation ACRYLAMIDE 丙烯酰胺 Final titre: 325 g/lt Fermentation time: 40-48 hrs Recovery yield: 98% AMOXICILLIN 阿莫西林ield: ＞90%(guaranteed; semi-continuous process with recycling) ＞95%(achieved; semi-continuous process with recycling) Amphotericin B两性霉素B Final titre: 10000U/ml(HPLC) Fermentation time: 130-140hrs Recovery yield: 70% ANDROSTENDIONE-SPIRONOLACTONE 雄烯二酮-螺内酯 Androstendione Final titre: 20 ± 2 g/lt Fermentation time: 96 ± 24 hrs Recovery yield: 90 % as Crystals 96% purity Sprironolactone Synthesis: 66% from AD APRAMYCIN Sulfate 硫酸安普霉素 Final titre: 8 g/l Fermentation time: 144 ±12 hrs Recovery yield: ≥80% ARACHIDONIC ACID 花生四烯酸 Final titre: 10 ±1 g/lt Fermentation time: 134 hrs Recovery yield: 80 ± 5% ARGININE精氨酸 Final titre: 75±5g/L Fermentation time: 50 hrs Recovery yield: 80％ as crystal 90％ feed grade ASTAXANTHIN 虾青素 Final titre: 3 g/lt Fermentation time: 180±10 hrs Recovery yield: 60% AVERMECTIN阿维菌素 Final titre: 5000 u/ml (+ 10%) Fermentation time: 260-280 hrs Recovery yield: 75% BACITRACIN-Zinc 杆菌肽锌 Final titre 1200u/mL Fermentation time: 36 hrs Recovery yield: ≥55 % BLEOMYCIN 博莱霉素 Final titre: 140±20mg/L Fermentation Time: 144±12hrs Recovery yield: ≥35% CABERGOLINE卡麦角林 By chemical synthesis from Lysergic acid 3.29k