Chapter3TransmissionofExcitationInNerveandMuscle(.ppt

Chapter 3 Transmission of Excitation In Nerve and Muscle  (兴奋在神经肌肉间的传递) Neuromuscular junction (神经肌肉接点): Belong to a kind of synapses in general (广义上属于一种突触) 1.The structure of neuromuscular junction  (神经肌肉接点的结构) Fig 3-2 Presynaptic membrane(接头前膜): Neuron membrane, it has synaptic vesicles which include chemical transmission- acetylcholine (Ach). (神经细胞膜，内有突触小泡， 含化学递质乙酰胆碱) 2. Transmission of Excitation In Neuromuscular Junction (兴奋在神经肌肉接点的传递) (1)Endplate potential, EPP (终板电位) about 50mv and miniature endplate potential, MEPP (小终板电位) about 0.5mv (2)Qualitative relation between N impulse and muscle contraction (N冲动与肌肉收缩在量上的关系) 1 : 1 Neuromuscular junction fatigue (神经肌肉接点疲劳) (3) Termination of excitation (兴奋的终止) acetylcholinesterase (乙酰胆碱酯酶); eserine毒扁豆碱 (依色林); curare (箭毒) (4) Reversal potential 逆转电位 (-15mv) Fig3-12 Ach-正离子通透性增加 当膜电位处于极化状态时： Ach引起内向电流（钠 内流钾外流) 当Ach引起的钠内流＝钾外流时的膜电位即 净电流为零－逆转电位 当膜电位处于去极化状态时： Ach引起外向电流（钾外流钠内流) 3. The Characters of Excitation Transmission On Neuromuscular Junction (神经肌肉接点兴奋传递的特点) (1)Unidirectional transmission (单向传导) Fig.3-4 (2)Synapse delay (time) (突触延搁) (3)Susceptibility (易感性 ) 1.enter“Chapter4 Excitation and contraction of muscle (肌肉的兴奋与收缩)”2.back to “introduction”3.over4.back to menu Chapter 4 Excitation and Contraction  of Muscle  (肌肉的兴奋与收缩) skeletal muscle Muscle cardiac muscle striated muscle smooth muscle 1.Minute Structure of Skeletal Muscle （骨骼肌的微细结构） Fig 4-1 (1)Myofibril and sarcomere (肌原纤维与肌小节) Skeletal muscle : n muscle fiber + C.T (骨骼肌)