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* * * * * Rosenberg and Waugh conducted a nationwide prospective study of 1,657 women initiating oral contraceptives or switching to a new oral contraceptive. Of the 293 women who discontinued oral contraceptives: 46% cited side effects as the reason 23% had no continuing need for contraception 14% reported method-related problems 17% had other unspecified reasons Source: Rosenberg MJ, Waugh MS. Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons. Am J Obstet Gynecol 1998;179:577-582. * * * * * * * * Effect of Drospirenone on Premenstrual Symptoms (change in Menstrual Distress Questionnaire score) Key points: Drospirenone has an effect on the perception of the severity of some common menstrual symptoms. Symptoms of water retention, negative affect, and increased appetite were less severe after 6 cycles of treatment with drospirenone. The impact of 3.0 mg drospirenone/30 μg ethinyl estradiol on women’s self-perception of menstrual health was evaluated during an open-label, 13-cycle study conducted in the US. The occurrence of menstrually related symptoms was assessed via a questionnaire completed at baseline and again at the end of cycle 6. The questionnaire was adapted from the Menstrual Distress Questionnaire (MDQ). It consisted of the following items: ? Impaired concentration: insomnia, forgetfulness, confusion, poor judgment, difficulty concentrating, distractibility, tendency to have minor accidents and poor motor coordination ? Negative affect: loneliness, sadness, tearfulness, moodiness, tension, anxiety, irritability, and restlessness ? Water retention: weight gain, painful or tender breasts, swelling of breasts or abdomen, and skin blemish or disorder ? Increased appetite ? Feeling of well-being ? Undesirable hair change The results of the questionnaire showed that drospirenone has an effect on the perception of the severity of some common menstrual symptoms. Symptoms of water retention, negative affect, and in