HIV global overview.Vermund.China.2008.pptVIP

HIV/AIDS IN WOMEN妇女与艾滋病 HIV/AIDS IN CHILDREN儿童和艾滋病 HIV/AIDS IN THE UNITED STATES美国的艾滋病 Preventing mother to child transmission PMTCT 预防母婴传播 ART in HIV/AIDS抗逆性病毒治疗和艾滋病 1-Year Mortality by Baseline WHO Stage CD4 Count Adults on ART 一年生存率 Many Correlations with Co-infections and Higher Viral Load 合并感染和高病毒载量 TB, helminths, malaria, herpes viruses, pneumonia Can control of OIs reduce HIV VL and slow disease progression and infectiousness of genital tract fluids? Conclusions 结论 More and more people have access to antiretroviral therapy ART 越来越多的人获得抗逆病毒治疗 Still, 4 persons are infected per year for every 1 who goes on ART 当每一人获得抗逆病毒治疗时，仍有4个人新感染 Combination HIV therapy has increased substantially the survival of HIV-infected persons 复合治疗能显著提高感染者生存率 Thank you 谢谢 Comments and questions welcome sten.vermund@vanderbilt.edu UNAIDS The variable risk of MTCT of HIV  with and without preventive interventions 母婴传播的不同危险度（有或没有预防干预） Source: Adapted from Cooper et al, J Acquir Immune Defic Syndr, 2002; and Mofenson of the National Institute of Child Health and Human Development. Biological effect: ART decreases MTCT 生物学效果：抗逆性病毒治疗降低母婴传播 Maternal Plasma HIV-1 RNA copies/mL 100K 40K-100K 3K-40K 400-3K Undetectable 400 HAART no therapy 0 10 20 30 40 50 60 Rates per 100 women ZDV Number of people on antiretroviral therapy in low- and middle-income countries, 2002–2005 2002-2005年中低收入国家中接受抗逆病毒治疗的人数 North Africa and the Middle East Europe and Central Asia East, South and South-East Asia Latin America and the Caribbean Sub-Saharan Africa Source: WHO/UNAIDS 2005 . Progress on global access to HIV antiretroviral therapy: An update on “3 by 5.” 0 200 400 600 800 1000 1200 1400 End 2002 Mid- 2003 End 2003 Mid- 2004 End 2004 Mid- 2005 End 2005 People receiving therapy thousands 7.1 Enrollment in the Lusaka ART Program May ’04 – Dec ’05 2004年5月-2005年12月在赞比亚路萨卡开展的抗逆病毒治疗的纳入人数 36,566 Enrolled 22,121 on ART Ref: Stringer JS et al. JAMA 2006 成人生存曲线 Ref: Strin