国内统一刊号.ppt

Bridging Bioinformatics and Chem(o)informatics Gary Wiggins School of Informatics Indiana University wiggins@ Yan He (SLIS MLS Student) Meredith Saba (SLIS MLS Student) Provocative Thought “While much bioscience is published with the knowledge that machines will be expected to understand at least part of it, almost all chemistry is published purely for humans to read.” Murray-Rust et al. Org. Biomol. Chem. 2004, 2, 3201. Overview of the Talk Review of ACS CINF 2004 Papers Review of Relevant Articles Public Chemistry Databases and Data Repositories with Bioinformatics Info/Links Overview of Web Services NIH-funded Projects Underway or Planned at Indiana University “The Bigger Picture — Linking Bioinformatics to Cheminformatics” American Chemical Society Division of Chemical Information (CINF) Symposium, Anaheim, Spring 2004 All-day session with 16 papers /new/docs/meetings/227nm/227cinfabstracts.htm Problems from ACS CINF 2004 Both technical and people factors hinder knowledge exchange between biology and chemistry. (Lipinski) People Problems per Chris Lipinski Meta data capture is complicated by people issues, particularly those between chemists and biologists. Discipline-based disconnects occur distressingly often and are frequently overlooked as a cause of lost productivity. Interdisciplinary Collaborations: Biology and Chemistry [What’s] “... important for these collaborations is, not only do you have to accept the other guy’s paradigm or at least live with it; you have to be willing to accept the other guy’s foibles or your perception of the other guy’s foibles (and recognize the opposite of this). We each have our own approaches to how we do science, and it’s just different cultures.” --Thom Kauffman interview in ACS LiveWire, March 2005, 7.3. /4librarians/livewire/2006/7.3/profile.html Some Questions from the ACS CINF 2004 Symposium Find all proteins related to protein A (i.e. within a given path length of A) in a protein interaction graph, and retrieve