树枝状大分子在生物成像中的应用解析.ppt

# Group Number: 33 Reporter: 刘涛 BMember: 曹志华 SBioimaging applications of Dendrimers 仿生 Mimicking nature Typical linear polymer Typical dendrimer Synthetic rout: divergent Synthetic rout: convergent -COOH -OH -NH2 -N3 -alkynyl -SH -ethylene PAMAM Gene Drug Vaccine Tissue Engineering Bioimaging FITC Rhred Rhodamine Achievements in the field of MRI The Nobel Prize Winners in Physiology or Medicine in 2003 for their Discoveries concerning MRI R1 DOTA Gd R2 Folic Acid Hyperbranched Polyester Boltorn H40 Preparation of H40-Based Unimolecular Micelles for Targeted Drug Delivery and MRI L1: Alkynyl- DOTA Gd L2: H40-based Unimolecular Micelles with DOTA Gd L3: H40-based Unimolecular Micelles with DOTA Gd and FA In Vitro Enhancement Effect of Unimolecular Micelles on MRI a Liver slices from white rabbit In Vivo Enhancement Effect of Unimolecular Micelles on MRI a b c d e f g h pre 0.5 h 1 h 2 h 4 h 10 h 20 h 30 h References: 1. Nature Biotechnology 23, 1517 - 1526 2005 2. Journal of the American Chemical Society, 132, 18158-18167 2010 3. Journal of Physical Chemistry B, 114 1751-1756 2010 4. Journal of the American Chemical Society, 133, 12507–12517 2011 5. Journal of the American Chemical Society, 133, 20507–20520 2011 6. Pharmaceutical Research, 28, 1500-1519 2011 7. Soft Matter, 6, 456-474 2010 8. Biomaterials, 32, 6595-6605 2011 . # * *