mTOR信号转导与肾脏损伤解析.pptVIP

Rapamycin ameliorates kidney ?brosis in Fibroblast-Tsc1-/- mice Summary (2) TSC/Rheb/mTORC1 signaling activation promotes fibroblast activation and kidney interstitial ?brosis. Rictor/mTORC2 in tubular cell survival and AKIRheb/mTORC1 in fibroblast activation and kidney fibrosisRictor/mTORC2 in fibroblast activation and kidney fibrosis Activation of mTORC2 signaling in the fibroblasts from the fibrotic kidneys Knocking down Rictor expression blocks TGFβ1-induced NRK-49F cell activation Creating mice with Specific deletion of Rictor in ?broblast Specific deletion of Rictor in ?broblast am