2008g11-细胞因子课件.pptVIP

complement,cytokine,CD,CAM 以生物学作用进行划分 以生物学作用进行划分 以生物学作用进行划分 以生物学作用进行划分 以生物学作用进行划分 以生物学作用进行划分 细胞因子受体 小 结 1.概念: cytokine; paracrine; autocrine; endocrine 2.作用的复杂性: cytokine 3.分类:cytokine 以生物学作用进行划分 课外阅读 Cytokines are a diverse group of intercellular signaling peptides and glycoproteins with molecular weights between 6000 and 60, 000. several hundred cytokines have been identified to date. Each is secreted by particular cell types in response to a variety of stimuli and produces characteristic effects on the growth, mobility, differentiation, or function of target cells. They are extremely potent compounds that act at concentration of 10-9 to 10-15 M by binding to specific surface receptors on target cells. Usually, cytokines act in either a paracrine manner or an autocrine manner. Cytokines produced by lymphocytes are also called lymphokines, whereas those produced by monocytes or macrophages are called monokines. 预 习 第十章 细胞免疫应答 -S-S- -S-S- -S-S- CC C C C1C3C2 C1C3C2 C1C3C2 C1C3C2 G 蛋白 免疫球蛋白超家族受体 I类细胞因子受体 II类细胞因子受体 TNF-R 趋化因子受体 IL-1 M-CSF C-kit IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 IL-9 IL-11 IL-12 IL-13 IL-15 OSM GM-CSF G-CSF LIF CNTF 生长激素催乳素 IFN-a IFN-b IFN-g TNF-a TNF-b CD40 神经生长因子（NGF） FAS IL-8 RANTES MIP-1 PF4 MCAF NAP-2 细胞因子受体分类 参与免疫应答与免疫调节 免疫应答识别（感应）阶段 IFN刺激APC MHC-II的表达 IL-1辅助T细胞活化 IL-10抑制抗原递呈 免疫应答细胞扩增阶段 IL-2、IL-4、IL-5、IL-6等促进T、B细胞的增殖与分化 TGF-b 抑制淋巴细胞增殖 免疫应答效应阶段 趋化因子吸引炎症细胞 TNF-α、IL-1、IFN-γ、GM-CSF等激活巨噬细胞，增强吞噬杀伤活性 TNF-α、TNF-β具有细胞毒性并刺激中性粒细胞 IFN-γ、抑制病毒复制 Function of cytokine Leukocyte differentiation antigen and Cell-adhesion molecules 白细胞分化抗原 （leukocyte differentiation antigen） - Leukocyte differentiation antigens are cell surface molecules which may appear on or disappear from cell membrane when stem cell differentiate into different lineage cells or when blood cells are in maturational stages and activation status. 血细胞在分化成熟为不同谱系、分化的不同阶段及细胞