curcumin.doc

Antischistosomal and liver protective effects of Curcuma longa extract in Schistosoma mansoni infected mice. El-Ansary AK, Ahmed SA, Aly SA. Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. With a view to clarify the induction of the Crabtree consequence in liver cells of S. mansoni infected mice, the curative effect of oil extract of C. longa was tested and compared to praziquantel (PZQ) the effective drug against all schistosome species occurring in man. Protein, glucose, glucose-6-phopsphatase, AMP-deaminase, adensoine deaminase, urea concentration, pyravate kinase (PK), phosphoenol pyruvate carboxykinase (PEPCK) and PK/PEPCK ratio were estimated. In addition, worm burden and ova count in mice infected with S. mansoni were elucidated. The result showed that C. longa normalized the concentration of protein, glucose, AMP-deaminase and adenosine deaminase, which were changed by infection. Moreover, it lowered pyruvate kinase level, while PZQ-treatment induced more elevation of this enzyme. PZQ was more effective in lowering worm burden while C. longa extract was more potent in reducing egg count. PMID:[PubMed - indexed for MEDLINE] 1: Acta Pol Pharm. 2007 Jan-Feb;64(1):53-61. Antihyperglycaemic effect of Ilogen-Excel, an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. Umamaheswari S, Mainzen Prince PS. Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India-608 002. Ilogen-Excel, an Ayurvedic herbal formulation is composed of eight medicinal plants (Curcuma longa, Strychnos potatorum, Salacia oblonga, Tinospora cordifolia, Vetivelia zizanioides, Coscinium fenestratum, Andrographis paniculata and Mimosa pudica). The present study evaluates the antihyperglycemic effect of Ilogen-Excel in streptozotocin induced diabetic rats. Rats were rendered diabetic by streptozotocin (STZ) (45 mg/kg body weight). Oral administration of Ilogen-Excel (50 mg/kg and 100 mg/k