20131023-dongcp-presentation@SHR.pptVIP

Therapeutic response to CDK4/6 inhibition n breast cancer deined by ex vivo analyses of human tumors Keywords: cell cycle, PD0332991, breast cancer, ER, ex vivo * ? 2012 Landes Bioscience 11:14, 2756-2761; July 15, 2012 Introduction Estrogen receptors are over-expressed in around 70% of breast cancer cases, referred to as ER-positive, and can be demonstrated in such tissues using immunohistochemistry. The result of both processes is disruption of cell cycle, apoptosis and DNA repair, and, therefore, tumour formation. HER2 is a member of the epidermal growth factor receptor (EGFR/ErbB