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58. Praziquantel Synergistically Enhances Paclitaxel Efficacy to Inhibit Cancer Cell Growth 吡喹酮增强紫杉醇疗效协同抑制癌细胞的生长 PLOS ONE 2012 《公共科学图书馆?综合》Abstract摘要The major challenges we are facing in cancer therapy with paclitaxel PTX are the drug resistance and severe side effects. Massive efforts have been made to overcome these clinical challenges by combining PTX with other drugs. In this study, we reported the first preclinical data that praziquantel PZQ , an anti-parasite agent, could greatly enhance the anticancer efficacy of PTX in various cancer cell lines, including PTX-resistant cell lines. Based on the combination index value, we demonstrated that PZQ synergistically enhanced PTX-induced cell growth inhibition. The co-treatment of PZQ and PTX also induced significant mitotic arrest and activated the apoptotic cascade. Moreover, PZQ combined with PTX resulted in a more pronounced inhibition of tumor growth compared with either drug alone in a mouse xenograft model. We tried to investigate the possible mechanisms of this synergistic efficacy induced by PZQ and PTX, and we found that the cotreatment of the two drugs could markedly decrease expression of X-linked inhibitor of apoptosis protein XIAP , an antiapoptotic protein. Our data further demonstrated that down-regulation of XIAP was required for the synergistic interaction between PZQ and PTX. Together, this study suggested that the combination of PZQ and PTX may represent a novel and effective anticancer strategy for optimizing PTX therapy.我们面临的主要挑战是用紫杉醇 PTX 治疗癌症和严重的副作用。努力克服这些临床挑战PTX与其他药物结合。PZQ和PTX的联合治疗也诱导显著的和激活凋亡级联。此外PZQ与PTX结合会导致更加明显抑制肿瘤的生长鼠移植瘤模型单独用药。 Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis通过微胞载体结合传送紫杉醇和坦螺旋霉素:药物动力学、疗效和代谢物组学分析。 PLOS ONE 2013 《公共科学图书馆?综合》Abstract摘要Background: Despite the promising anticancer efficacy observed in preclinical studies, paclitaxel and tanespimycin 17- AAG combination therapy has yielded mea