孟鲁司特联合布地奈德治疗儿童哮.docVIP

孟鲁司特联合布地奈德治疗儿童哮喘的疗效及对IL-4、IL-8、TNF-a的影响 陈可彬 1,2 宋蒙蒙3 1 青岛大学医学院，山东青岛 266003 2 费县人民医院儿科四区，273400 3 费县人民医院手术室，273400 摘要：目的：探讨孟鲁司特联合布地奈德治疗儿童哮喘的疗效及对IL-4、IL-8、TNF-a的影响。方法：选择2013年11月~2014年11月我院收治的支气管哮喘患者80例作为研究对象，采取随机数字表法随机分为观察组和对照组，每组各40例，两组患者均予平喘、持续低流量吸氧及抗生素控制感染等常规对症治疗。对照组予布地奈德气雾剂100-200ug/d，每天2次。观察组加用孟鲁司特钠10 mg，每晚1次。7 d为一疗程，连续治疗14d。对治疗后的疗效进行评价，并比较两组患者治疗前后IL-4、IL-8、TNF-a水平的变化情况。结果：观察组患者治疗后的总有效率达95%，对照组患者治疗后的总有效率达75%，两组临床疗效比较，差异具有显著性（P＜0.05）。治疗前对两组的炎症因子IL-4、IL-8、TNF-a水平进行比较，组间差异不显著，治疗后结果显示，两组的炎症因子IL-4、IL-8、TNF-a水平均较治疗前明显下降。且观察组治疗后的炎症因子IL-4、IL-8、TNF-a水平分别较对照组比较显著降低，差异具有显著性（P＜0.05）。结论：孟鲁司特联合布地奈德治疗儿童哮喘可以提高疗效，考虑可能与其降低IL-4、IL-8、TNF-a等炎症因子而抑制炎症反应的作用有关。 关键词：儿童哮喘；孟鲁司特；布地奈德；IL-4；IL-8；TNF-a The curative effect of Montelukast Combined with budesonide in the treatment of children with asthma and the influence of IL-4, IL-8, TNF-a Abstract: Objective: To evaluate the clinical efficacy of Montelukast Combined with budesonide in the treatment of children with asthma and the influence of IL-4, IL-8, TNF-a. Methods: from November 2013 to November 2004 in our hospital were in patients with bronchial asthma 80 cases as the research object, take random number table method were randomly divided into observation group and control group, each with 40 cases in each, two groups of patients were treated with asthma, continuous low flow oxygen and antibiotics to control infection and other conventional symptomatic treatment. The control group was treated with Budesonide Aerosol 100-200ug/d, 2 times a day. The observation group was added with 10 mg, 1 times per night. 7 d for a course of treatment, continuous treatment 14D. The efficacy of treatment was evaluated, and the changes of TNF-a, IL-8 and IL-4 levels were compared between the two groups before and after treatment. Results: the total effective rate of the observation group was 95%, and the total effective rate was 75% in the control group, and the difference was significant (P two). Before treatm