antihistamine.pptVIP

Antihistamines Serotonin Agonists Histamine Antagonists H 1 receptors inhibit smooth muscle contraction decrease wheal, flare,and itch decrease secretions: salivary and lachrymal CNS: sedation H 2 receptors inhibit gastric acid secretion decrease content and volume of gastric juice fasting, food stimulated and nocturnal H 1 antagonists Relief of manifestations of immediate-type hypersensitivity reactions allergic rhinitis cold remedies newer agents “selective” for peripheral H 1 receptors less sedation (dose dependant) Antihistamine Products sedating diphenhydramine (Benadryl) chlorpheniramine