Extraction of Correlated Gene Clusters by Multiple Graph Comparison.ppt

Bio 101: Genomics Computational Biology Protein2: Last weeks take home lessons Net1: Todays story goals Networks Why model? Types of interaction models In vivo (classical) in vitro Human Red Blood CellODE model Factors Constraining Metabolic Function Physicochemical factors Mass, energy, and redox balance: Systemic stoichiometry osmotic pressure, electroneutrality, solvent capacity, molecular diffusion, thermodynamics Non-adjustable constraints System specific factors Capacity: Maximum fluxes Rates: Enzyme kinetics Gene Regulation Adjustable constraints Dynamic mass bal