DWI在脑部的应用概要.ppt

Diffusion weighted MR imaging in non-infarct lesions of the brain DWI在非梗塞性脑病变中的应用 Introduction Diffusion weighted imaging (DWI) is based on the sensitivity of MR to microscopic mobility of water molecules within tissues. DWI基于MR对组织内水分子微观运动的敏感性 DWI consists of a DW image and an apparent diffusion coefficient (ADC) map. DW image, together with qualitative and quantitative assessment of the ADC map has been widely used in the diagnosis of acute cerebral infarction, owing to the reliable distinction of cytotoxic and vasogenic edema. 由于DWI联合定性及定量的ADC图可以鉴别细胞毒性和血管源性水肿，已广泛地应用在急性脑梗塞的诊断 Edema is a non-specific reaction of brain parenchyme to diffenernt factors ,which can be differentiated by DWI. DWI可鉴别不同因素导致的脑实质的非特异性反应--水肿 Introduction Cytotoxic edema – characterized by abnormal cellular uptake of water and myelin edema – characterized by intramyelinic accumulation of vacuolated or free water – have high signal intensity on the diffusion trace, with decreased ADC as a result of isotropically restricted water diffusion. On the other hand,vasogenic edema, caused by increased permeability of the blood–brain barrier, and interstitial edema, caused by subependymal water diffusion in acute hydrocephalus have intermediate signal on the DW image with increased ADC DWI区分水肿的性质： 细胞毒性水肿和和髓鞘性水肿——由于同向性弥散受限，弥散相呈高信号，ADC值下降； 血管源性水肿和间质性水肿——弥散不受限，弥散相呈中等信号，ADC值升高。 Introduction Although DWI has been tried for different organ systems, it has been found its primary use in the central nervous system. The most widely used clinical application is in the detection of hyperacute infarcts and the differentiation of acute or subacute infarction from chronic infarction 尽管DWI已经应用在不同系统的器官，但是主要应用在中枢神经系统。 临床最广泛的应用是诊断超急性脑梗塞和鉴别急性或亚急性脑梗塞与陈旧脑梗塞 Introduction Recently DWI has been applied to various other cerebral diseases. 现在DWI被应用在多种脑部疾病 In this paper，I demonstrate different DWI patterns of non-infarct lesions of the brain which are hyperintense in the diffusion trace image, such as infectious,