复方黄柏液涂剂柳氮磺吡啶栓治疗溃疡性直肠炎随机对照研究(江学良).docVIP

医学新知杂志 2012年第2期 复方黄柏液涂剂涂剂与柳氮磺吡啶栓治疗溃疡性直肠炎随机对照研究 江学良 中国人民解放军济南军区总医院消化科 山东省济南市 250031 摘要 目的：研究复方黄柏液涂剂涂剂保留灌肠治疗溃疡性直肠炎疗效，并与柳氮磺吡啶栓进行对照。 方法：60例溃疡性直肠炎患者（其中男32例，女28例，平均年龄34.7岁，病程3 月-1 年）随机分为A、B两组，A组应用复方黄柏液涂剂涂剂保留灌肠（100mL, 每晚1次，共30天）治疗， B组应用柳氮磺吡啶栓剂（SASP，0.5g, 每日2次，共30天）治疗。观察两组治疗后腹泻症状缓解情况、临床总疗效，临床症状缓解情况，肠镜缓解情况，组织学缓解情况. 结果：腹泻症状缓解情况：与B组比较, A组患者腹泻症状恢复正常时间(11.2 ±3.8, vs 17.7 ±5.1天)及黏液脓血便消失时间(8.9±4.6, vs 14.2±4.5,天)明显缩短(P0.05),临床总疗效:A组(完全缓解20例，有效9例，无效1例)显著优于B组 (完全缓解12例，有效15例，无效3例，P 0.05).临床症状缓解情况: A组(完全缓解20例，部分缓解9例，无效1例)显著优于B组 (完全缓解12例，部分缓解15例，无效3例，P 0.05). 肠镜缓解情况:A组(完全缓解20例，部分缓解9例，无效1例)显著优于B组(完全缓解12例，部分缓解15例，无效3例，P 0.05). 组织学缓解情况: A组(完全缓解19例，部分缓解10例，无效1例)显著优于B组 (完全缓解11例，部分缓解16例，无效3例，P 0.05). 胃肠道反应情况: A组未见不良反应，而B组则有肝功能损伤、水样大便次数增多、皮疹各2例不良反应. 结论：复方黄柏液涂剂涂剂保留灌肠治疗溃疡性直肠炎安全有效。 关键词：溃疡性直肠炎；复方黄柏液涂剂涂剂；柳氮磺吡啶栓 A randomized controlled clinical trials of Compound Phellodendron liquid and Sulfasalazine suppositories in the treatment of ulcerative proctitis Jiang Xue-Liangn. Department of Gastroenterology, Chinese PLA General Hospital of Jinan Command Area, Jinan 250031, Shandong Province,ChinaCorrespondence to: Jiang Xue-Liang. Email:jiangxueliang678@126.com 【Abstract】 Objective:To evaluate the therapeutic effects of retention enema with Compound Phellodendron liquid in the treatment of ulcerative proctitis . Methods: Sixty ulcerative proctitis patients were randomly divided into two groups: Group A compound phellodendron liquid retention enema group (n =30) and Group B Sulfasalazine suppositories (n =21). Clinical effects and safety were compared between the two groups. Results: Compared with group B，Group A had an obviously shorter diarrhea recovery time[(11.2 ±3.8)d, vs (17.7 ±5.1)d, 2,P0.05];a shorter extinction time about the bloody diarrhea and mucus in stools[(8.9±4.6), vs (14.2±4.5)d, P0.05].The overall clinical efficacy of group A (complete remission in 20 cases, improvement in 9 patients, ineffective in one case) was better than that in group B (complete remission in 12 cases, imp