线粒体与细胞凋亡研究进展.docxVIP

·综 述·线粒体与细胞凋亡研究进展曾凯星11.中山大学药学院，广州，510006【摘要】线粒体是细胞凋亡的执行者。当线粒体受到内外环境因素的影响时，会造成线粒体通透性转运孔持续开放，细胞色素C的释放、Caspase蛋白的激活以及活性氧的作用。本文阐述了三者变化的多种机制，同时也论述了Bcl-2家族和AIF因子在凋亡过程中的调节作用机制，为寻找肿瘤靶点提供机遇。【关键词】线粒体；细胞凋亡；线粒体通透性转运孔；细胞色素C；Caspase Study Progress of Mitochondria and ApoptosisKai-xing ZENG11.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 51006, ChinaAbstract: Mitochondria are the executors of apoptosis. When the mitochondria are affected internal and external environmental factors, can cause mitochondrial permeability transition pore remain open, release of cytochrome C and activation