培训课件-时间药理学与药物评价.pptVIP

Liver Spleen P＜0.05 P＜0.01 Clofarabine 50mg/kg, ip, 15d，mice,n=20 Organ Coefficient （3）Valproic Acid pharmacokineties 17：00 5：00 Vd (L/kg) 0.34±0.03 0.49±0.20﹡ Ke ( /h) 2.05±0.29 1.98±0.69 t1/2 (h) 0.35±0.06 0.39±0.15 Cl (L/kg.h) 0.70±0.10 0.86±0.06﹡﹡ Auc (mg/l.h) 73.50±11.20 58.90±3.60﹡﹡ Valproic acid 50mg/kg, iv,ICR mice, n=10 Time (min) Valproic acid plasma level Valproic acid osmotic miuipump (1.062mg/h) Constant-rate administration ICR mice , n=10 y=35.8+13.9cos(15°/h .t - 236°) 55.1±12.3mg/L 25.6±6.0mg/L Tramadol kinetic parameters (52mg/kg, ip, n=20) ° 16:00 4:00 t1/