Schiff堿论文酰腙化合物及1-(2-吡啶基)乙酮类Schiff碱配合物的合成表征及生物活性研究.docVIP

Schiff碱论文：酰腙化合物及1-（2-吡啶基）乙酮类Schiff碱配合物的合成、表征及生物活性研究 【中文摘要】由于过渡金属Schiff碱配合物具有多样的配位几何构型,及金属离子配位数的多样性,在配位化学领域该类配合物受到人们的广泛关注。此类化合物通常含有O、N等多个给体原子,容易与金属离子结合形成种类繁多的金属配合物,其杂化轨道上的N原子具有孤对电子,从而赋予了其重要的化学及生物学上的意义。由于Schiff碱类化合物在众多领域均有广泛的应用前景,如催化领域、磁性材料、生物活性等领域,近年来已成为人们十分关注的研究对象。脲酶抑制剂是一种抑制脲酶活性减缓尿素分解释放氨气的,避免氨水浓度升高造成的不良影响。国内外脲酶抑制剂的种类大体分为三种:一种有机化合物,酚醌类,杂环类等;二是磷酰胺类化合物,三就是重金属离子。近年来,为了解决控制氮素损失减少及其造成的一系列水体污染、土体污染、土壤中氨和硝酸盐累积对作物造成的农产品污染等环境问题。脲酶抑制剂的研究成为国内外许多学者的关注热点。本文主要分为两大部分:一,合成了8个酰腙化合物,对它们进行了X-射线单晶结构测定、红外光谱和元素分析的表征。二、以1-(2-吡啶基)乙酮为原料合成了6个Schiff碱配体及5个Schiff碱单核的Cu、Zn配合物,6个Schiff碱双核及链状的Cu、Cd配合物,对它们进行了X-射线单晶结构测定、红外光谱和元素分析的表征。考察了溶剂、阴离子、桥连基团和配体对配合物结构的影响。测定了部分化合物的脲酶抑制活性。结果表明:部分化合物有较好的活性。配合物中金属离子和配体结构对于活性都有一定的影响。 【英文摘要】Considerable attention has been focused on the coordination chemistry of transition metal complexes with Schiff base ligands due to their remarkable flexibility in the coordination geometry and the coordination numbers of the metal ions. The Schiff base complexes usually contain O, N and some other donor atoms, which easily form versatile complexes with metal ions. On its hybridization orbit’s N atom which has orphaned to the electron has entrusted with in its important chemistry and the biology significance. The Schiff base complexes have been received much attention and have been widely used in many fields, such as catalysis, magnetic materials, biological activity and many other fields.Urease inhibitors is a kind of inhibiting urease active slow release urea decomposition, avoid ammonia concentration caused by elevated the adverse effects. Domestic and international urease inhibitors types can be divided into three kinds: 1) organic compounds, phenolic quinonoids classes, heterocyclic etc; 2) phosphorus acetobromoglucose, 3) heavy metal ions. In recent years, in order to control the nitrogen loss and the water pollution, soil pollution, soil of ammonia and nitrate accumulation of agricultural crop cause environmental