卡維地洛与美托洛尔对心肌梗塞后大鼠血流动力学的影响.docVIP

【摘要】 　　目的：研究比较卡维地洛与美托洛尔对大鼠心肌梗塞后血流动力学的影响。方法：结扎大鼠左冠状动脉建立急性心肌梗塞模型, 术后24 h 存活的147只SD大鼠以简单随机法分为心肌梗塞对照组(MI 组, n = 43), 美托洛尔（20mg/kg·d)治疗组（M组，n=42）,卡维地洛（10 mg/kg·d)治疗组(C组, n = 42)，另设假手术组(S 组, n = 20)；各组按观察时点48 h 和4周，再分为: MI 组48 h 和MI 组4周，M组48 h 和M组4周， C组48 h 和C组4周，S组48 h和S组4周。M组、C组于术后24h直接灌胃法给药，并于术后48h及4周对相应的观察组进行血流动力学测定。结果：（1）与S 48h组相比，MI 48h组的主动脉收缩压（SBP）、舒张压（DBP）和平均压（MAP）、左心室收缩压（LVSP）和左心室内压最大上升和下降速率（±dp/dt）均显著降低（P0.05～0.01）；（2）与S 4周组比较，MI 4周组心率、LVSP和±dp/dt显著降低（P0.05～0.01）, 左室舒张末压（LVEDP）则显著升高（P0.01），而主动脉SBP、DBP和MAP无显著变化；（3）与MI 48h组相比，C48h组的SBP、MAP、LVSP、±dp/dt和心率均显著降低（P0.05～0.01），LVEDP无显著变化，而M 48h组血流动力学指标均无显著差异；（4）与MI 4周组相比，C4周组SBP、DBP、MAP和LVEDP均显著降低（P0.05），LVSP、±dp/dt等无显著变化；而M 4周组只有LVEDP和心率显著降低（P0.01）。结论：大鼠心肌梗塞后，可以发生血流动力学异常改变和左室功能异常。较长时间（4周）卡维地洛应用能有效降低AMI后大鼠左室舒张末压，改善血流动力学和左室功能，美托洛尔亦有相似作用。 【关键词】 心肌梗塞　血流动力学过程　卡维地洛　美托洛尔 　　Comparative effects of carvedilol and metoprolol on hemodynamics in rats after acute myocardial infarction/WANG Yao|guo, GUO Wen|an, DU Xin|qing, CHEN Yue|feng, XU Chao|xiang// 　　Abstract：Objective:To compare the effects of carvedilol and metoprolol on hemodynamics in rats after acute myocardial infarction.Methods:AMI model was established with the ligation of anterior descending coronary artery in female SD rats.Twenty|four h after operation,147 survivors were randomly assigned to AMI control(MI,n=43) group，metoprolol (20mg/kg·d) treatment (M,n=42) group, carvedilol (10mg/kg·d) treatment (C,n=42) group, while sham|operated rats (S,n=20) were selected randomly as non|infarction control.According to observation time, each group was subdivide into two subgroups:MI 48h group,MI 4 weeks group,M 48h group,M 4 weeks group,C 48h group,C 4 weeks group,S 48h group,S 4 weeks group.Metoprolol was given to group M and Carvedilol was given to group C by gastric gavage at 24h after ligation.The hemodynamics of each group was studied at 48 hours and 4 weeks after ligation.Results:(1)Compared with sham|operated 48h group, systolic blood pressure(SBP), diastolic bloo