葛均波院士谈心脏病细胞治疗课件.pptVIP

Left ventriculography of anterior wall infarction 6 months, fi ve patients had serious adverse events (four?in the CDC treatment group [24%] vs one control [13%];?p=1?00) and two additional patients who received CDCs?had such events by 12 months (p=0?36). In these six?patients in the CDC group, serious adverse events?included one acute myocardial infarction, two cases of?chest pain, one coronary revascularisation, one implantable?defi brillator insertion for prophylactic indications,?and two other non-cardiac events. One patient in the?control group had atypical chest pain. All but one of the?serious adverse events were regarded as unrelated or?unlikely to be related to the study treatment. The?exception was a non-Q wave myocardial infarction in one?patient who had received 25 million CDCs 7 months?previously; the data and safety monitoring board regarded?this event as possibly related to treatment. No patients?had ventricular fi brillation or sustained ventricular tachycardia?during the monitoring period. One patient from?the high-dose CDC group had atrial fi brillation. Incidence?of non-sustained ventricular tachycardia did not diff er ?between groups; one patient from the high-dose CDC?group had non-sustained ventricular tachycardia of?11 ectopic beats 2 weeks after infusion, one patient who?received the high dose level and one patient who received?the low dose level had 5–10 ectopic beats, and two controls?had 5–10 ectopic beats. We noted no deaths or cases of?MACE or tumour formation on MRI. * CDCs治疗组与对照组舒张末期容积、收缩末期容积和LVEF无明显差异。 * 在第6个月时，MRI分析结果显示CDCs治疗组患者心脏瘢痕面积减少，活力心脏面积增加，局部心肌收缩功能改善，局部收缩期室壁增厚。 * Figure 5: Myocardial regeneration in rats treated with CDCs ?Representative images of Masson trichrome-stained sections of vehicle control (A) and intracoronary CDC-treated (B) rat hearts 3 weeks after treatment (scar tissue stained?blue and viable myocardium stained red). Enlarged regions show striking diff erences in transmurality of scar and extent of viable myoca