给药系统设计及分子学基础-2015.pptVIP

* Case File — Sediment Optimized formulation * Case File — Sediment Conventional tablet * Furosemide BCS IV pKa 3.9 Half life less than 2 h Solubility pH dependent Side effect：Peak diuresis effect Major absorption site ： upper gastrointestinal tract Erratic absorption, poor bioavailability 3-4 times a day， non-compliance Case File — Bioadhesion * Marketed formulation Lasix Retard? 60mg Limitation : insufficient time in the stomach * CR Layer IR Layer Designed formulation Total: 60 mg Loading dose 30% Maintenance dose 70% Bioadhesion Expansion * Gastric Retention System is