GI functio development and microbiota.docVIP

Ital J Pediatr.?2013 Feb 24;39:15. doi: 10.1186/1824-7288-39-15. Gastrointestinal function development and?microbiota. Di Mauro A1,?Neu J,?Riezzo G,?Raimondi F,?Martinelli D,?Francavilla R,?Indrio F. Author information Abstract The intestinal?microbiota?plays an important role in the development of post-natal gastrointestinal functions of the host. Recent advances in our capability to identify microbes and their function offer exciting opportunities to evaluate the complex cross talk between?microbiota, intestinal barrier, immune system and the?gut-brain axis. This review summarizes these interactions in the early colonization of gastrointestinal tract with a major focus on the role of intestinal?microbiota?in the pathogenesis of feeding intolerance in?preterm?newborn. The potential benefit of early probiotic supplementation opens new perspectives in case of altered intestinal colonization at birth as preventive and therapeutic agents. Microbiologyopen.?2013 Apr;2(2):215-25. doi: 10.1002/mbo3.64. Epub 2013 Jan 24. Microbiota?diversity and stability of the?preterm?neonatal ileum and colon of two infants. Barrett E1,?Guinane CM,?Ryan CA,?Dempsey EM,?Murphy BP,?OToole PW,?Fitzgerald GF,?Cotter PD,?Ross RP,?Stanton C. Author information Abstract The composition of the?microbiota?associated with the human ileum and colon in the early weeks of life of two?preterm?infants was examined, with particular emphasis on the Lactobacillus and Bifidobacterium members. Culturing work showed that bifidobacteria and lactobacilli in the ileostomy changed over time, compared with the colostomy effluent where there was far less variation. The colostomy infant was dominated by two phyla, Actinobacteria and Firmicutes, while in the ileostomy samples, Proteobacteria emerged at the expense of Actinobacteria. Bacteroidetes were only detected following the reversal of the ileostomy in the final fecal sample and were not detected in any colonic fluid samples. Clostridia levels were unstable in