代谢组学方法与应用.pptVIP

Lung cancer diagnosis Abdul-Hamid M. Emwas et al. Metabolomics. 2013 Disease DS Wishart. Drugs in R D. 2008 Drug discovery To monitor drug metabolism and toxicity. Cost increases Success rate decrease Drugs Contents 1. Background 2. Workflow 3. Application 4. Challenge Challenge Biomarker discovery High dimensional data (Curse of dimensionality) Synergy effect of metabolites (Combinatorial explosion) Integration of different instrumental platforms Integration of different -omics techniques Matteo Cassotti etc. Chemometr. Intell. Lab. 2014 Assuming 10000 models per second. Combinatorial explo