斑疹伤寒制_培训课件.pptVIP

1850-1934中国共15次大流行 50年代云贵川；60年代黑龙江、 吉林、辽宁 70年代以后未再发生本病大流行 * Rickettsial infection stimulates partial DC maturation, as shown by the upregulation of major histocompatibility complex (MHC) and co-stimulatory molecules. Bone- marrow-derived DCs from susceptible murine hosts that are infected in vitro with Rickettsia fail to stimulate Rickettsia-specific CD4+ T-cell differentiation into TH1 or TH2 cells that produce interferon- (IFN-) or interleukin (IL)-4, respectively. Suppressed effects on CD4+ T-cell responses are associated with IL-10 production by DCs as well as increased num