Bioinormatics Algorithms.docVIP

Bioinformatics Algorithms 课程： Gene Ontology 唐昆 GeneOntology-tk Methods to Detect Signatures of Positive Selection 汪思佳 SijiaWang_naturalselction_PIC隐马可夫模型 HMM_gyzheng_PICBBioinformatics Analysis of Next-Generation Sequencing Data-Epigenome and Chromatin Interactome 魏刚 Bioinformatics course Introduction into evolution Philipp Khaitovich evo_history 概率 严军 无课件 Alignment Stefan Grunewald Lecture_3_all Database Peter Serocka Lecture-DB-Searches BLAST-Introduction Exercises PowerSequencing 杨力 无课件 Cluster and Networks 韩敬东 han_MolecularNetworksSIBS Phylogeny Stefan Grunewald Bioinf_class2013_11_21 Regulatory Network 胡海洋(from Philipp Group) Regulatory_network_part1 Regulatory_network_part2 case_study1 Gene Ontology 唐昆 Gene Ontology: provides a controlled vocabulary to describe gene and gene product attributes in any organism Purpose: unified, unambiguous, structured nomaclatures for the use of computer program Ps:nomaclatures - 命名法 Nomenclature is a system of words used in particular discipline. It is used in respect of giving names systematically following the rules to all known living.The word nomenclature is derived from the Latin nomen - name, calare - to call. GO terms: Three fundamental sets: 1)cellular component (where is it) 2)molecular function (what it does there) 3)biological process (how it does it) Structure: Directed Acyclic Graph 1)Single direction 2)Zero or more Children 3)One or more parents 4)Linked as synonyms Relationship: “IS_A” one term is a subclass of another class. “Golgi apparatus” is a kind of “cell organelle” “Part_of” one term is a component of another term. “Golgi apparatus” is a part of “cell” “IS_Synonym” Under the bigger umbrella of OBO Open Biological Ontology Usage: Integrating gene/protein information from different organisms assigning functions to protein domains finding functional similarities in genes predicting the likelihood that a particular gene is involved in diseases that ha