第3章 药物代谢动力学1-课件.pptVIP

第 3 章 药物代谢动力学 药物代谢动力学(pharmacokinetics) Pharmacokinetics简称药动学，主要研究药物的体内过程及体内药物浓度随时间变化的规律。 前者主要以文字和图表定性地描述药物在体内的变化过程；后者主要以数学模型与公式定量地描述药物随时间改变的变化过程。 Fig.3-1 Schematic representation of the ADME process of a drug . Drug was absorbed from the sites of administration into the systemic circulation, in which they reversiblely bind to albumin or other proteins. The bound drug is inactive, therefore it is limited its systemic distribution, metabolisum and excretion. Only free drug is able to cross membrane to reach tissues, sites of drug action and be metabolized or excreted. 一、药