Control of cell signaling by PTPases.pptVIP

Control of cell signaling by PTPases  Why study Protein Tyrosine Phosphatases (PTPs) ? The size and complexity of the Protein Tyrosine Phosphatase (PTP) familyequal that of the tyrosine kinases Cbl degradation ((role of Src in YP-ing and activating Cbl ?) SHIP heterodimerization ! binding may be cis binding may reflect PTP acting as ligand rather than as receptor Ligands can affect -phosphorylation (YP, auto-de-P ?) -dimerization (pos. or neg.) -sensitivity to redox-regulation -heterodimerization -association with other proteins , or substrates (liprins, …) Su et al., 1999