核心文章(不同剂量瑞舒伐他汀治疗急性冠状动脉综合征及疾病预测指标相关性研究).docVIP

不同剂量瑞舒伐他汀治疗急性冠状动脉综合征及疾病预测指标相关性研究 【摘要】目的 探讨不同剂量瑞舒伐他汀治疗急性冠状动脉综合征以及TIMI危险积分与血浆N末端前脑利钠肽（NTpro-BNP）水平及血清肌钙蛋白I(TNI)的相关性。方法 收集2013年5月-2014年9月在我院接受治疗的98例急性冠状动脉综合征患者，随机分为实验组（瑞舒伐他汀PCI手术前40mg/d，术后20mg/d）和对照组（术前术后均10mg/d）。观察两组患者治疗后TIMI危险积分NTpro-BNP、TNI、不良事件发生率。采用AQT快速免疫分析法检测患者血浆（NTpro-BNP）水平及TNI水平，研究TIMI危险积分、NTpro-BNP水平及TNI的相关性。结果 实验组患者治疗后TIMI危险评分、NT-proBNP、TNI水平、各个时期的不良事件发生率较对照组低，P＜0.01，差异具有统计学意义。随着TIMI危险评分的升高，NTpro-BNP和BNP水平均升高，NTpro-BNP升高更加显著，P＜0.01，差异具有统计学意义。Spearman 等级相关分析可知，NTpro-BNP与 TIMI正相关 TNI 正相关TIMI 与 TNI 无相关性TIMI危险积分与NTBNP相关性良好，与NTBNP一样用于识别高危患者，与TNI无相关性急性冠脉综合征患者TIMI危险积分NTpro-BNP、TNI都有所下降，不良事件发生率低，值得在临床上推广。 【关键字】急性冠状动脉综合征；血浆N末端前脑利钠肽；TIMI危险积分；肌钙蛋白I Different doses of rosuvastatin with acute coronary syndrome and disease-related predictors of statin therapy research [Abstract] Objective To explore different doses of rosuvastatin treatment of acute coronary syndrome and former TIMI risk score and plasma N-terminal brain natriuretic peptide (NTpro-BNP) levels and serum troponin I (TNI) correlation.Methods Collected in May 2013 -2014 in September in our hospital treated 98 cases of patients with acute coronary syndrome were randomly divided into experimental group (rosuvastatin statins before PCI surgery 40mg / d, after 20mg / d) and the control group (before and after surgery were 10mg / d). TIMI risk score, NTpro-BNP, TNI, the incidence of adverse events were observed after treatment. Rapid adoption AQT Immunoassay plasma (NTpro-BNP) levels and TNI level, research TIMI risk score, NTpro-BNP levels and TNI correlation.Results After the experimental group patients TIMI risk score, NT-proBNP, TNI level, various periods of adverse event rates lower than the control group, P 0.01, the difference was statistically significant. With the TIMI risk score increased, NTpro-BNP and BNP levels were elevated, NTpro-BNP increased more significantly, P 0.01, the difference was statistically significant. Spearman rank correlation analysis shows, NTpro-BNP was positively correlated with