2型糖尿病并发骨质疏松的相关危险因素分析.docVIP

西安交通大学学报（K学版） Journal of Xi’an Jiaotong UniversityCMedical Sciences) 2型糖尿病并发骨质疏松的相关危险因素分析 李小凤、施秉银2，庞雅玲、王养维1 (1.陕西竹人民医院内分泌科，陕西西安710068; 2.西安交通大学医学院第一附屈医院内分泌科，陕西西安710061) 摘要：《的分析2型糖尿病（T2DM)患者并发骨质疏松后骨密度（BMD)的改变及相关因素，为早期诊断、早期防治 糖尿病并发背质疏松提供理论依据。方法根据受试者的骨密度值将糖塚病患者分为伢质疏松组和非骨质疏松组， 对比两组T2DM患者的性别、年龄、体重指数（BMI)、糖尿病病程、空腹血糖（FPG)、糖化血红蛋白（HbAlC)、空腹胰 岛索（FIns)、胰岛素敏感指数（1SI)、尿D蛋白定鱼（ALb)、24h尿蛋白定童、血淸钙、瞬和碱性磷酸酶（ALP)等指标之 间的差异，并进行相关性分析。蛣果骨质疏松(OP)组与非OP组比较，OP组年龄大，病程长，体重指数低，骨密度 低，碱性磷酸酶高，胰岛素敏感指数低，糖化血红蛋白髙、空腹胰岛素低、24 h尿蛋白定童和尿白蛋白定童高，r检验有 统计学差异（P0. 05);而空腹血糖、血磷、血钙位无统计学差异。T2DM患者的BMD与年龄、病程、糖化血红蛋白、 24h尿蛋白定童、Alb、ALP负相关，与BMKISI正相关；与血钙、血磷、空腹血糖无相关性。结论髙龄、低体重、病程 长、血糖控制不良、胰岛功能差、胰岛素抵抗、卨的血碱性磷酸酶、糖诚病贤病都是糖尿病合并骨质疏松的危险因素。 关键词：2型糖尿病；骨密度；骨质疏松；危险因素 中图分类号：R587. 1 文献标志码：A 文章编号：1671-8259(2010)02-0197-03 Relative risk factor analysis of type 2 diabetes complicated with osteoporosis LI Xiao-feng1，SHI Bing-yin2，PANG Ya-ling1，WANG Yang-wei1 (1. Department of Endocrinology，Shaanxi Provincial Peoples Hospital, Xi’an 710068； 2. Department of Endocrinology，the First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China) ABSTRACT： Objective To investigate the changes of bone mineral density (BMD) in patients with type 2 diabetes (T2DM) complicated with osteoporosis (OP) and analyze the factors related to diabetic osteoporosis (DOP) so as to provide theoretical evidence for early diagnosis and prevention of osteoporosis complicated with T2DM. Methods According to their BMD values, patients were divided into OF group and non-OP group. Then wc compared differences in sex, age, body mass index (BMI), diabetes duration, fasting plasma glucose (FPG)， glycosylated hemoglobin (HbAlc)，fasting insulin (Fins), insulin sensitivity index (ISI)，quantitative of urinary albumin (ALb)? quantitative of urinary protein in 24 hours, serum calcium (Ca)，phosphorus (P) and alkali phosphatase level (ALP), and made correlation analysis. Results Compared with those in non-OP group, patients in OP group had older age，long