生化复习题(英文).docVIP

Ⅰ. Filling banks . 1. Asymmetries of membrane are maintained during fusion. The inside of the vesicles because the outside of the plasma membrane and the cytoplasmic side . 2. Many proteins are targeted by signal sequences to their correct destinations , ensuring that they will end up in the correct membrane or cell compartment . 3. Secific protein are synthesized either on free or on membrane-bound polyribosomes . 4. Mitochondrial (mt) genome encodes proteins, with its own system , but majority of mitochondrial proteins are synthesized outside mitochondrion . 20~60 amino acid sequences mediate target proteins to the matrix,so-called translocation . 5.Importins and exportins are involved in transport of macromolecules in and out of the nucleus . 6 . Most eases of Zellweger syndrane are due to mutations in genes encoding proteins involved in import of peroxisomal proteins . 7. Signal peptide emerges from large subunits of ribosome . It recognized by signal recognition particle , which blocks further translation after about 70 amino acids , so-called elongation arrest . Then above complex bound docking protein on membrane . 8. Chaperones are proteins that prevent faulty folding and unproductive interactions of other proteins . 9. The fungal metabolite brefelding A prevents GTP from binding to ARF , which inhibits the entire coating process . 10.Vesicles non-clathrin --coated vesicle lie at the heart of intracellular transport. 1 . Peroxisomal proteins are ( A ) A Responsible for metabolism of FA , lipids , cholesterol , purline , aa , H2O2 B Its importing are mediated only by PTS sequences C Only com(酶) is needed during its importing D Lack of these protein can cause cardiovascular disease 2 . Zellweger syndrome is caused by ( C ) A Tissues can not synthesizes cytoplasmic enzymes B Abnormal metabolism of heme C major finding is involved in nerologic impairments D Mutations in genes encoding proteins in