疮疡灵的处方改进及其抗皮肤真菌感染疗效观察.docVIP

疮疡灵的处方改进及其抗皮肤真菌感染疗效观察 胡倩1王林泉1刘元瑞2常凤鸣1闫国立3* 【摘要】 目的 改进疮疡灵的处方组成，添加具有抗真菌活性的中药成分制成疮疡灵5号并观察其抗皮肤真菌感染的临床疗效。方法 将70例皮肤真菌感染患者随机分为疮疡灵5号组（治疗组）和酮康唑组（对照组）对比2组临床疗效。结果 治疗组和对照组体癣的痊愈率和总有效率比较差异有统计学意义（Ρ＜0.05），手足癣的痊愈率和总有效率比较差异有统计学意义（Ρ＜0.01）。结论 改进后的复方中药制剂疮疡灵5号组（治疗组）对皮肤真菌感染疗效明显，使用方法简便，适于在临床和基层部队推广使用。 【关键词】疮疡灵；处方改进；皮肤真菌感染；疗效 Improve the prescription of chuangyangling and observate the curative effection of anti fungal skin infection HU Qian1, WANG Lingquan1, LIU Yuangrui2,CHANGFengming1.YANGuoli* 1. Henan Provincial Corps Hospital , Chinese Peoples Armed Police Forces, Zhengzhou，450052，China；2. Chinese Peoples Armed Police Institute for drug control;3 Henan University of Traditional Chinese Medicine Zhengzhou 450008，China ABSTRACT OBJECTIVE: Improve the prescription of chuangyangling , add with antifungal activity of traditional Chinese Medicine to develop the compound preparation of traditional Chinese Medicine chuangyangling-5 and observe the clinical effection of anti fungal skin infection. METHODS: Select 70 patients with cutaneous fungal infections and divide randomly them into chuangyanglin-5 group (treatment group)and Ketoconazole group (control group) to comparize them clinical effections. RESULTS: The cure rate and the total efficiency of tinea corporis have the different statistically significant between the treatment group and control group.(p0.05). The cure rate and the total efficiency of foot and hand tinea have the different statistically significant between the treatment group and control group.(p0.01). CONCLUSION: The improved compound traditional Chinese medicine preparations chuangyangling-5 have the effection of the skin fungal infections, the method use simply, suitable for use in clinical and basic forces to promote and use. KEWWORDS ChuangYangLing; Improvement of prescription; Fungal infections of the skin; Curative effect 疮疡灵（武卫药准字:60105）是我院自制外用中药复方制剂。能有效改善皮肤局部的血液循环,提高血供及局部细胞的渗透性，具有消炎止痛、活血化瘀、去腐生肌的作用〔1〕。在治疗顽固性溃疡、褥疮、外伤、冻疮等方面取得了良好的效果。我院在原疮疡灵的配方基础上筛选添加具有抗真菌活性的中药成分，研制