血管硬化剂栓塞犬肝硬化模型食管静脉丛对门静脉的影响.docVIP

介入治疗上消化道出血对犬肝硬化模型门静脉的影响 孙顺吉1 龙金凤2 蹇兆成1冯学强1 赵凯1 王秀春1 王鹏1 【摘要】目的 通过建立犬肝硬化模型，探讨血管硬化剂栓塞食道静脉丛对门静脉的影响，为血管硬化剂更好的在肝硬化门脉高压症的应用提供必要的实验依据。方法 建立犬肝硬化模型，随机分为对照组（钢圈栓塞），无水乙醇组和鱼肝油酸钠组，采用经皮穿刺门静脉，逆行进入胃底食管静脉丛注射栓塞剂进行栓塞，术后第1周、第2周检测肝功能变化情况，术后第二周取出标本，光镜下观察门静脉的损伤情况。结果ALT值：对照组先升高后降低，术后2周与术前比较差异性不明显(P0.05)，无水乙醇组和鱼肝油酸钠组术后第1周和第2周均明显高于对照组(P0.01)；TBIL值：各组之间以及术前与术后间的监测值变化不大，相互之间比较均无明显差异性(P0.05)；门静脉损伤程度：鱼肝油酸钠组略轻于无水乙醇组，但二者之间比较无统计学意义(P0.05)，但上述两组损伤程度均明显重于对照组(P0.01)。结论 PTVE是门脉高压所致的胃底食管静脉曲张破裂所致大出血的有效治疗方法之一，但在应用液态栓塞剂时需注意对门静脉的损伤，必要时可联合应用钢圈栓塞。 【关键词】肝硬化 动物模型；食管静脉丛栓塞 硬化剂；门静脉损伤 病理性 Study on the influence of portal vein after esophageal varicose vein plexus embolization by vascular hardener in dog liver cirrhosis model SUN Shun-ji, LONG Jin-feng, JIAN Zhao-cheng, ZHAO Kai, FENG Xue-qiang, WANG Xiu-chun, Wang Peng. Vascular Interventional Department, Affiliated Hospital of Weifang Medical University, Wei’fang, 261031, China [Abstract] Objective To investigate the influence of portal vein after esophageal varicose vein plexus embolization by vascular hardener in dog liver cirrhosis model. to provide the necessary experimental basis for the better application of vascular hardening agent in portal hypertension. Methods After the establishment of the dog __________________________ 基金项目：潍坊市科技局立项课题（201002064） 作者单位：潍坊医学院附属医院血管介入科（孙顺吉，蹇兆成，赵凯，冯学强，王秀春，王鹏），潍坊医学院附属医院影像中心（龙金凤） liver cirrhosis model, the model were randomized into control (rims embolization), anhydrous alcohol group and cod liver oil sodium group, using percutaneous portal vein, retrograde enters the stomach bottom esophageal varicose vein plexus injection embolic agents for embolization, The liver function will be detected in the first and second week postoperative, at the same time the portal vein specimens will be gathered in the second week which will be observed by the light-microscopy. Results ALT values: the control group rose at first, then decreased and no difference lied between postoperative and preoperative (P 0.05), The value of anhydrous a