转基因动物2.pptVIP

Formation of the primitive streak is one of the earliest events in gastrulation, followed by the movement of cells to the distal portion of the embryo culminating in the formation of the structure known as the node, or the organizer. If Nor-1 mutant can affect formation of the node? a number of markers for the node is tested The markers are included Lim1, Hnf3b In wild type embryos, lim1 antisense probe stains most of the anterior primitive streak-derived tissues but is down-regulated after E7.5. with expression limited to the periphery of the node (Fig. 4a). In the retarded Nor-1-deficie