不同抗生素治疗下呼吸道感染的效果分析.docVIP

不同抗生素治疗下呼吸道感染的效果分析 　　[摘要] 目的 探讨不同抗生素治疗下呼吸道感染的临床效果。 方法 选取本院2010年5月～2012年5月收治的160例下呼吸道感染患者，将其随机分为甲、乙、丙、丁4组，分别采用头孢曲松钠、头孢噻肟钠、阿奇霉素及左氧氟沙星药物治疗，比较4种药物的治疗效果、不良反应发生率及患者的治疗费用。 结果 4组患者的治疗效果及不良反应发生率差异无统计学意义（P0.05）；甲组及丁组患者治疗成本明显低于乙组及丙组，差异有统计学意义（P0.05）。 结论 4种药物的临床治疗效果无显著差异，安全性基本一致，头孢曲松钠和左氧氟沙星成本较低，因此在临床治疗时可优先考虑，降低患者的治疗成本。 　　[关键词] 抗生素；下呼吸道感染；临床效果；不良反应；经济性 　　[中图分类号] R978.1 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0085-02 　　Clinical effect analysis of different antibiotics in the treatment of lower respiratory infection 　　LI Li 　　Department of Pharmacy，People′s Hospital of Pingxiang City in Jiangxi Province，Pingxiang 337055，China 　　[Abstract] Objective To investigate the pharmacy effect of four different antibiotics in the treatment of lower respiratory infection.Methods 160 patients with lower respiratory infection in our hospital from May 2010 to May 2012 were selected as research objects and randomly divided into A，B，C，D group，each group received ceftriaxone，cefotaxime，azithromycin and levofloxacin respectively，the treatment effect，adverse reaction incidence and patient treatment costs of the four different antibiotics were compared.Results For the treatment effect and adverse reaction incidence，there was no significant difference among the four groups （P0.05）.The treatment costs of the group A and group D was significantly lower than that of group B and group C，there was statistical difference（P0.05）.Conclusion The four different antibiotics with similar treatment effect and security，but due to the lower cost of ceftriaxone and levofloxacin，can be considered as treatment preferences for lower respiratory infection to reduce treatment costs. 　　[Key words] Antibiotics；Lower respiratory infection；Clinical effect；Adverse reaction；Economical efficiency 　　下呼吸道感染是临床常见的呼吸道疾病，发病率较高，多由革兰氏阴性菌感染引起，临床研究结果显示喹诺酮类、头孢菌素、大环内酯类、青霉素等广谱抗生素药物治疗效果显著[1]。然而近年来，抗菌药物品种不断增多并在临床广泛应用，导致细菌耐药力提高，同时药物费用不断升高导致患者治疗成本明显增加，加重了患者家庭的经济负担，为对不同抗生素药物治疗下呼吸道感染的临床效果进行比较，本研究对本院收治的160例下呼吸道感染患者进行探讨，现报道如下。 　　1 资料与方法