高强度聚焦超声联合全身化疗对结直肠癌肝转移的近期疗效.docVIP

高强度聚焦超声联合全身化疗对结直肠癌肝转移的近期疗效 　　[摘要] 目的 观察高强度聚焦超声（以下简称HIFU）联合全身化疗治疗结直肠癌肝转移的近期疗效。 方法 选取结直肠癌肝转移患者103例，随机分为HIFU联合化疗组和常规化疗组。结果 联合化疗组近期有效率为74.0%，常规化疗组近期有效率为54.7%，两组比较有显著性差异（P0.05）。 结论 HIFU联合全身化疗治疗结直肠癌肝转移有更好的近期临床疗效。 　　[关键词] 结直肠癌；肝转移；高强度聚焦超声；化疗 　　[中图分类号] R735.3 [文献标识码] B [文章编号] 1673-9701（2013）32-0154-03 　　The recent curative efficacy of therapy of high intensity focused ultrasound combined with systemic chemotherapy treatment on liver metastasis of colorectal cancer 　　ZHANG Weixing ZHONG Yu PENG Biling HUANG Yao DENG Weiping 　　Department of General Surgery， Shenzhen Futian People’s Hospital， Guangdong Province， Shenzhen 518033， China 　　[Abstract] Objective To observe the recent curative efficacy of therapy of high intensity focused ultrasound （HIFU） combined with Systemic chemotherapy treatment on liver metastasis of colorectal cancer. Methods A total of 103 patients with liver metastasis of colorectal cancer were divided into two groups randomly. Combined chemotherapy group of patients received HIFU combined with systemic chemotherapy and conventional chemotherapy group received systemic chemotherapy only. Results Combined chemotherapy groups recent effective rate was 74.0% and conventional chemotherapy group was 54.7%. The difference between two groups had significant difference （P0.05）. Conclusion HIFU combined with systemic chemotherapy have a better recent curative efficacy in the treatment of the liver metastasis of colorectal cancer. 　　[Key words] Colorectal cancer； Liver metastasis； High intensity focused ultrasound； Systemic chemotherapy 　　约50%～60%的结直肠癌患者确诊时已发生转移，其中80%～90%的患者初次评估时肝脏转移灶无法手术切除[1]，对这部分患者的治疗仍以全身化疗为主，但有效率只有20%左右，近年来随着新药的应用，报道有效率可达70%[2]。高强度聚焦超声（high intensity focused ultrasound，HIFU）是一种非侵入性、安全、高效的可直接杀灭实体肿瘤的治疗手段，对肝脏肿瘤的完整治疗率超过80%[3]，可作为对结直肠癌肝转移综合治疗中有效的辅助治疗手段之一。本文旨在探讨高强度聚焦超声联合全身化疗对结直肠癌肝转移患者的临床治疗效果。 　　1 资料与方法 　　1.1 一般资料 　　选取我院2007年1月～2012年12月结直肠癌伴肝转移患者103例，男67例，女36例，年龄29～82岁，平均（63.40±8.93）岁。所有病例均经临床病理或影像学及可靠的血清肿瘤标记物检查确诊，无肝外转移，且肝脏病灶不适宜手术切除，转移肿瘤