《药物非房室模型分析.pptVIP

Mechanisms of altered elimination Verapamil has been shown to elevate serum digoxin concentrations in patients receiving both drugs concurrently. A study by Pedersen et al (Clin Pharmacol Ther 30:311-316, 1981.) examined this interaction with the following results.: Treatment Digoxin Dig + verapamil CLT 3.28 2.17 CLR 2.18 1.73 CLNR 1.10 0.44 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. STEADY-STATE VOLUME OF DISTRIBUTION Cf Cbp Cf Cbt VP VT Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0.