左乙拉西坦对癫痫患儿的神经保护作用.docVIP

左乙拉西坦对癫痫患儿的神经保护作用 　　[摘要] 目的 观察左乙拉西坦（LEV）对癫痫患儿血清神经元特异性烯醇酶（NSE）的影响，探讨LEV对癫痫患儿的神经保护作用。 方法 参与本次实验研究的有40例癫痫患儿和10例健康儿童。采用放免法测健康儿童及癫痫患儿发作72 h之内血清NSE的浓度，以此为标准对LEV治疗的癫痫患儿予8周评估。将40例癫痫患儿随机分成LEV组和VPA（丙戊酸钠）组，分别监测两组癫痫患儿在治疗前（0周）与治疗后2周、8周血清NSE浓度变化。结果 干预前LEV与VPA两组的NSE指标水平无显著差异（P = 0.398），明显高于正常儿童组（P 0.01）；治疗2周后，LEV组、VPA组的NSE指标均有所下降，与正常儿童间的血NSE指标差异均显著（P 0.01）；治疗8周后，NSE值在三组间有显著性差异，LEV组与正常儿童间的差异不显著（P = 0.669），VPA组与LEV组及正常儿童组的差异显著（P 0.01），均高于二者的平均值。结论 左乙拉西坦会降低癫痫患儿血清NSE的水平，可能具有神经保护作用。 　　[关键词] 癫痫；左乙拉西坦；丙戊酸钠；神经元特异性烯醇酶 　　[中图分类号] R742.1 [文献标识码] B [文章编号] 1673-9701（2013）25-0031-02 　　Neuroprotection effect of LEV in children with epilepsy 　　QIU Anli1 REN Zhimin2 FANG Shaohong2 CHEN Guiying1 HAO Yanqiu2 　　1.Department of Pediatrics， Harbin Children’s Hospital， Harbin 150010， China； 2.Department of Pediatrics， the Second Hospital Affiliated to Harbin Medical University， Harbin 150086， China 　　[Abstract] Objective To investigate effects of levetiracetam （LEV） on serum neuron-specific enolase （NSE） for understanding its neuronal protection in children with epilepsy. Methods Forty children with epilepsy and ten healthy children participated this study. The children with epilepsy were randomized into two groups： one was treated under LEV （n=20） and the other was under VPA （n=20） for eight weeks. The NSE level in the serum was assessed in the healthy children once. The NSE level of children with epilepsy was assessed within 72 hours after seizure before the treatment as well as at 2 and 8 weeks after the treatment. Results Before the treatment， the serum NSE level was comparable between children treated with VPA and children treated with LEV （P = 0.398）， but was higher than that in healthy children （P 0.01）. After the two-week-treatment， the NSE level was reduced in children treated with VPA （P 0.01） and children treated with LEV（P 0.01） but was still significantly greater than that of normal children （P 0.01）. After the eight-week treatment， the NSE level was comparable between chil