曲安奈德鼻喷雾剂对变应性鼻炎患者血清白介素—4和γ—干扰素水平的影响及疗效观察.docVIP

曲安奈德鼻喷雾剂对变应性鼻炎患者血清白介素—4和γ—干扰素水平的影响及疗效观察 　　[摘要] 目的 观察曲安奈德鼻喷雾剂对变应性鼻炎患者血清白介素（IL）-4和γ-干扰素（IFN-γ）水平的影响及疗效观察。 方法 72例变应性鼻炎患者随机分为观察组和对照组。两组均予以口服氯雷他定片10 mg，1次/d，共4周，观察组加用曲安奈德鼻喷雾剂喷鼻，2次/d，连用4周。观察两组患者治疗前后血清IL-4和IFN-γ水平的变化，并进行临床疗效及安全性的观察。 结果 治疗4周后，两组患者血浆IL-4水平均较前明显下降，IFN-γ水平均较前明显上升（P 0.05），未发生严重药物不良反应。 结论 曲安奈德鼻喷雾剂治疗变应性鼻炎疗效确切、安全性较好，作用与其能降低血清IL-4水平、提高血清IFN-γ水平密切相关。 　　[关键词] 变应性鼻炎；曲安奈德鼻喷雾剂；白介素-4；γ-干扰素 　　[中图分类号] R765.21 [文献标识码] B [文章编号] 1673-9701（2013）25-0044-03 　　Influence and efficacy of triamcinolone acetonide nasal spray on serum interleukin-4 （IL-4） and interferon-γ （IFN-γ） levels of allergic rhinitis patients 　　LIAO Jianping1 LV Xiaoping2 　　1.E.N.T. Department， Yuhang Traditional Chinese Medical Hospital of Hangzhou， Zhejiang， Hangzhou 311106， China； 2.Department of Clinical Laboratory， Taizhou Hospital of Zhejiang Province， Linhai 317000， China 　　[Abstract] Objective To discuss the influence and curative observation of triamcinolone acetonide nasal spray on serum interleukin-4 （IL-4） and interferon-γ （IFN-γ） levels of allergic rhinitis patients. Methods Seventy-two cases of allergic rhinitis patients were divided into observation group and control group at random. The patients in two groups were given loratadine tablets （10mg） one time daily for 4 weeks， while the patients in control group were given triamcinolone acetonide nasal spray two times daily for 4 weeks additionally. The changes of serum IL-4 and IFN-γ levels of patients in two groups were observed before and after medical treatment， and the clinical curative effect and security observation were carried out. Results After 4 weeks’ medical treatment， the IL-4 level in plasma of patients in two groups declined obviously than before， while IFN-γ level rose obviously than before （P 0.05）. Conclusion Triamcinolone acetonide nasal spray has reliable curative effect on allergic rhinitis with high security， and mechanism of action has close effect on reducing serum IL-4 level and enhancing serum IFN-γ level.