欣普贝生与催产素对40例足月引产疗效分析.docVIP

欣普贝生与催产素对40例足月引产疗效分析 　　摘 要 目的：探讨欣普贝生和催产素在足月引产中的应用效果。方法：收治足月引产产妇80例，随机分成对照组和观察组各40例。观察组给予普贝生10mg塞阴道引产；对照组给予催产素2.5U加入5%葡萄糖溶液500ml中静滴引产，观察比较两组宫颈评分的变化、引产成功率、临产时间、剖宫产率和对新生儿的影响。结果：观察组产妇用药后宫颈评分明显高于对照组，24小时引产成功率90%。对照组24小时引产成功率60.0%，两组比较差异有统计学意义（P0.05）。欣普贝生的不良反应为子宫过度刺激，发生率为5%，但发生率低，将药取出后好转。结论：欣普贝生是一种安全、有效的促宫颈成熟药物。 　　关键词 足月引产 欣普贝生 缩宫素 应用效果 　　Abstract Objective：To explore the effect of suppositories and oxytocin application in induced term labor.Methods：We selected 80 cases of maternal induced term labor in 2012 September to 2013 October.These patients were randomly divided into the observation group and the control group with 40 cases in each.Methods：The observation group was given 10mg propess into the vagina to induce labor.Continuous intravenous drip of 2.5U oxytocin with 5% glucose solution 500ml of the control group to induce labor.We observed index of the two groups，such as cervical score，the successful rate of induced labor，labor time，the rate of cesarean section and the effect of cesarean section to neonatal.Results：The observation group of cervical score was significantly higher than control group.The successful rate of induced labor in 24 hours of observation group is 90% and control group is 60.0%.The difference between the two groups was significant（P0.05）.The adverse reaction of propess was uterine hyperstimulation and the incidence rate was 5%.If we take the medicine out，the adverse reaction will be better.Conclusion：Propess is a safe，effective agent in promoting cervical ripening. 　　Key words Induced term labor；Propess；Oxytocin；The application effect 　　宫颈成熟度是引产是否成功一个重要因素。欣普贝生是一种新型的控释前列腺素E[1]，成为欧美国家常用的引产药物之一，近年来开始在我国应用。但对于欣普贝生的引产效果分析，国内外报道较少。为此，2012年9月-2013年10月应用欣普贝生对足月的妊娠患者引产，并与传统催产素引产效果比较，现报告如下。 　　资料与方法 　　2012年9月-2013年10月收治足月引产产妇80例。引产原因：死胎44例，胎儿畸形36例。随机分成对照组和观察组各40例，年龄23～38岁，平均28.6岁，平均孕周（40.2±0.6）周，平均宫颈评分（5.2±0.3）分，两组孕妇平均年龄、孕周及宫颈评分等方面差异无统计学意义。 　　方法：两组先行阴道检查和宫颈Bishop评分，再给予NST检查为有反应型。观察组产妇消毒外阴在无菌操作下，将欣普贝生栓剂10mg置于阴道后穹窿，给药后产妇平卧2小时后可自由活动，若12小时内出现临产、宫缩